The role of nanotopographical extracellular matrix (ECM) cues on vascular endothelial cell (EC) organization and function is not well-understood despite the composition of nano- to micro-scale fibrillar ECMs within blood vessels. collagen films that induce parallel EC alignment prior to stimulation with disturbed flow resulting from spatial wall shear stress gradients. Using real time live-cell… Continue reading The role of nanotopographical extracellular matrix (ECM) cues on vascular endothelial
Author: monossabios
statement Neuromyelitis optica spectrum disorder (NMOSD) is a rare Emodin autoimmune
statement Neuromyelitis optica spectrum disorder (NMOSD) is a rare Emodin autoimmune disease of the central nervous system that primarily attacks the optic nerves and spinal cord leading to blindness and paralysis. cord leading to blindness and paralysis [1]. NMO was first described and coined in the late 1800s but only recognized to be an entity… Continue reading statement Neuromyelitis optica spectrum disorder (NMOSD) is a rare Emodin autoimmune
In this issue Mossé and coworkers report the results of preclinical
In this issue Mossé and coworkers report the results of preclinical testing of a novel ALK/ROS1 inhibitor PF06463922 in neuroblastoma. relapse of fatal therapy-resistant lesions. Since the original identification of activating somatic mutations in neuroblastoma in 2008 multiple large-scale sequencing studies have established a consensus mutation Amiloride HCl rate of approximately 8% with amplification of… Continue reading In this issue Mossé and coworkers report the results of preclinical
Motivation for reward drives adaptive behaviors whereas impairment of reward perception
Motivation for reward drives adaptive behaviors whereas impairment of reward perception and experience (anhedonia) can contribute to psychiatric diseases including depression and schizophrenia. stimulation. This chronic mPFC overactivity also stably suppresses natural reward-motivated behaviors and induces specific new brainwide functional interactions which predict the degree of anhedonia in individuals. These findings describe a mechanism by… Continue reading Motivation for reward drives adaptive behaviors whereas impairment of reward perception
Background Paget’s disease of bone (PDB) is associated with a germline
Background Paget’s disease of bone (PDB) is associated with a germline mutation in /p62 (mutations and measles virus have been implicated. a role in defining phenotype and that this may become more visible in a well characterized cohort. Methods This is an observational study focused on a cohort of patients with PDB drawn from the… Continue reading Background Paget’s disease of bone (PDB) is associated with a germline
Dementias are among the most common neurological disorders and Alzheimer’s disease
Dementias are among the most common neurological disorders and Alzheimer’s disease (AD) is the most common cause of dementia worldwide. of FTDs are collectively known as tauopathies due to the abundant accumulation of pathological tau inclusions in the brain. The precise role tau plays in disease pathogenesis remains an area of strong research focus. A… Continue reading Dementias are among the most common neurological disorders and Alzheimer’s disease
Background As part of the planning process for new research the
Background As part of the planning process for new research the literature on community-based participatory research (CBPR) approaches for promoting physical activity in African American communities was systematically reviewed. design three had a quasi-experimental design three had a randomized controlled design and one was a case study. Conclusions Additional CBPR studies and faith-based interventions are… Continue reading Background As part of the planning process for new research the
The ability to quantify levels of target analytes in biological samples
The ability to quantify levels of target analytes in biological samples accurately and precisely in biomonitoring involves the use of Atropine highly sensitive and selective instrumentation such as tandem mass spectrometers and a thorough understanding of highly variable matrix effects. of laboratory data are achieved these effects must be characterized and controlled. Here we present… Continue reading The ability to quantify levels of target analytes in biological samples
BACKGROUND Sclerostin is an endocrine regulator in chronic kidney disease –
BACKGROUND Sclerostin is an endocrine regulator in chronic kidney disease – mineral and bone disorder (CKD-MBD). test yielded almost 2-fold higher sclerostin values throughout all sample types. Spike recovery and linear dilution studies revealed a higher accuracy of the TECOmedical assay (97% and 96%) compared to the Biomedica assay (118% and 78%). Sclerostin levels were… Continue reading BACKGROUND Sclerostin is an endocrine regulator in chronic kidney disease –
The studies of stem cell behavior and differentiation in a developmental
The studies of stem cell behavior and differentiation in a developmental context is complex time-consuming and expensive and for this reason cell culture remains a method of choice for developmental and regenerative biology and mechanistic studies. anti-mouse VE-cadherin to isolate and characterize mouse ECs because these antibodies are commercially available and their use has been… Continue reading The studies of stem cell behavior and differentiation in a developmental