Objectives To spell it out coping in mothers of adolescents with type 1 diabetes and to examine the association among mothers’ diabetes-related stress and coping strategies and maternal psychological stress (e. major depression quality of life and family discord. Data on glycemic control were collected CUDC-101 from adolescents’ medical charts. Results Solitary/divorced mothers and mothers of color were significantly more likely to use disengagement coping strategies (e.g. avoidance) than White and married/partnered mothers. Mothers’ use of main control coping (e.g. problem solving) and secondary control coping (e.g. acceptance) strategies was related to fewer symptoms of panic (= ?.51 ?.39) and depression (= ?.32 PPP2R1B ?.37) and less family discord (= ?.22 ?.30 all < .05). Mothers’ use of disengagement coping strategies was related to higher symptoms of panic (= .30) and major depression (= .27 both < .01). Further secondary control coping was found to mediate the relationship between diabetes-related stress and maternal symptoms CUDC-101 of panic and major depression. Maternal coping was CUDC-101 not significantly associated with adolescent results. Conclusions The ways in which mothers of adolescents with type 1 diabetes deal with diabetes-related stress are CUDC-101 associated with mental distress and family conflict. By identifying and improving mothers’ coping through testing and targeted interventions we may have the potential to improve both maternal and adolescent results. = .10 or larger in multiple regression analysis. Sobel checks (33) were used to assess whether the mediation effects or whether coping accounted for the relationship between the self-employed and dependent variables were significant. Given that our data are cross-sectional these analyses do not indicate a causal relationship between variables and thus the proposed mediational effects are considered exploratory. Results Maternal Psychological Stress All the mothers in our sample reported some diabetes-related stress on the RSQ; scores ranged from 5-22 having a mean total stress score of 12.4 (± 3.4). Approximately 18% of the mothers obtained above the medical cutoff for major depression with a imply score of 10.2 (± 8.3) within the CES-D. Approximately 13% of the mothers obtained above the medical cutoff for panic having a mean score of 32.4 (± 9.3). Demographic Variations in Coping Analyses of variance were carried out to examine demographic variations in mothers’ use of the. Significant racial/ethnic differences emerged in the use of disengagement coping; mothers of color used significantly more disengagement coping strategies (mean = 14.1) than White colored mothers (mean = 12.2) = .013. A similar effect was found for marital status; single/divorced mothers used significantly more disengagement coping strategies (imply = 14.1) than married/partnered mothers (mean = 12.1) = .005. No demographic variations were found in the use of main control or secondary control engagement coping strategies and maternal coping was not related to child gender maternal education family income or type of insulin therapy (pump vs. injection). Child age and duration of diabetes were not significantly related to maternal coping or any of the results variables so they were not included in further analyses. Associations between Maternal Coping and Maternal and Adolescent Adjustment Bivariate correlations indicate the associations among mothers’ diabetes-related stress and coping maternal mental distress diabetes-related family conflict adolescent adjustment and glycemic control. As seen in Table 2 mothers’ reports of diabetes-related stress were significantly associated with their symptoms of major depression (= .25) and panic (= .27 both CUDC-101 < .01) and family discord (= .30 = .001) and secondary control coping (= ?.43 < .001). Further mothers’ use of main control coping strategies was related to fewer symptoms of major depression (= ?.32) and panic (= ?.51 both < .001) and family discord (= ?.22 = .024). Similarly mothers’ use of secondary control coping strategies was related to fewer symptoms of major depression (= ?.37) and panic (= ?.39 both < .001) and family discord (= ?.30 = .001). On the other hand disengagement CUDC-101 coping was related to higher symptoms of major depression (= .27) and panic (= .30 both < .005). Table 2 Descriptive.