Objective(s): Lately, the chemistry of Tetrazolo[5′,1′:2,3][1,3,4]thiadiazepino [7,6-b] quinolines have obtained considerable attention due to their man made and effective natural importance which displays a multitude of natural activity. artificial tetrazolo[5′,1′:2,3][1,3,4]thiadiazepino[7,6-8.4, ArH), 7.97 (d, 1H8.4, ArH), 7.78 (s, 1H, ArH). Anal. Calcd. for C11H6N6S: C, 51.96; H, 2.38; N, 33.05; S, 12.61. Found out: C, 52.02; H, 2.65; N, 33.50; S, 12.06. 8-Methyltetrazolo[5′,1′:2,3][1,3,4] thiadiazepino[7,6-b]quinoline (3b) Produce: 92%; mp 215-217C; IR (KBr) cm-1: 3054, 3019 (CH aromatic), 2953, 2929, 2888 (CH aliphatic), 1607 (C=C), 1568 (C=N), 1058 (N-N), 828 (C-S). 1H NMR (400 MHz, CDCl3, 25C, ppm) : 8.53 (s, 1H, ArH), 8.29 (s, 1H, ArH), 8.03 (d, 1H, 8.4, ArH), 7.77 (d, 1H, 8.4, ArH), 7.72 (s, 1H, ArH), 2.62 (s, 3H), 13C NMR (100 MHz, CDCl3, 25C, ppm) : 155.4, 149.2, 148.1, 145.9, 142.1, 140.1, 136.4, 128.9, 127.5, 126.2, 126.1, 21.8. Anal. Calcd. for C12H8N6S: C, 53.72; H, 3.01; N, 31.32; S, 11.95. Found out: C, 52.82; H, 3.05; N, 32.50; S, 11.86. 8-Methoxytetrazolo[5′,1′:2,3][1,3,4] thiadiazepino [7,6-b]quinoline (3c) Produce: 88%; mp 222-224C; IR (KBr) cm-1: 3080, 3056 (CH aromatic), 2970, 2937, 2831 (CH aliphatic), 1623 (C=C), 1573 (C=N), 1061 (N-N), 844 (C-S). 1H NMR (400 MHz, CDCl3, 25C, ppm) : 8.55-7.65 (m, 5H, ArH), 3.85 (s, 3H, OCH3). Anal. Calcd. for C12H8N6OS: C, 50.70; H, 2.84; N, 29.56; S, 11.28. Found out: C, 50.90; H, 2.61; N, 30.05; S, 11.46. 8-Ethyltetrazolo[5′,1′:2,3][1,3,4]thiadiazepino[7,6-b]quinoline (3d) Produce: 88%; mp150-152C; IR (KBr) cm-1: 3051 (CH aromatic), 2967, 2933, 2876, (CH aliphatic), 1612 (C=C), 1570 (C=N), 1052 (N-N), 835 (C-S). 1H NMR (400 MHz, CDCl3, 25C, ppm) : 8.55-7.70 (m, 5H, ArH), 2.80 (q, 2H, 5.4, CH2CH3). 1.25 (t, 3H, 5.4, CH2CH3). Anal. Calcd. for C13H10N6S: C, 55.30; H, 3.57; N, 29.77; S, 11.36. Found out: C, 55.86; H, 3.91; N, 30.12; S, 11.72. 8-Ethoxytetrazolo[5′,1′:2,3][1,3,4] thiadiazepino[7,6-b]quinoline (3e) Produce: 95%; mp137-140C; IR (KBr) cm-1: 3064 (CH aromatic), 2990, 2926, 2831 (CH 196868-63-0 supplier aliphatic), 1621 (C=N), 1593 (C=N), 1056 (N-N), 839 (C-S). 1H NMR (400 MHz, CDCl3, 25C, ppm) : 8.55-7.72 (m, 5H, ArH), 4.42 (q, 2H, 5.4, CH2CH3). 1.45 (t, 3H, 5.4, CH2CH3). Anal. Calcd. for C13H10N6OS: C, 52.34; H, 3.38; N, 28.17; S, 10.75. Found out: C, 52.63; H, 3.97; N, 28.59; S, 11.12. 8-Chlorotetrazolo[5′,1′:2,3][1,3,4] thiadiazepino[7,6-b]quinoline (3f) GSS Produce: 93%; mp 224-225 C; IR (KBr) cm-1: 3068, 3047 (CH aromatic), 1623 (C=C), 1555 (C=N), 1055 (N-N), 837 (C-S). 1H NMR (400 MHz, CDCl3, 25C, ppm) : 8.92 (s, 1H, ArH), 8.52 (s 1H, ArH), 8.05 (s 1H, ArH), 7.82 (d, 1H8.4, ArH), 7.78 (d, 1H8.4, ArH). Anal. Calcd. for C11H5ClN6S: C, 45.76; H, 1.75; N, 29.11; S, 11.11. Found out: C, 45.82; H, 1.98; N, 30.08; S, 11.72. 7-Methyltetrazolo[5′,1′:2,3][1,3,4] thiadiazepino[7,6-b]quinoline (3g) Produce: 90%; mp172-174C; IR (KBr) 196868-63-0 supplier 196868-63-0 supplier cm-1: 3039 (CH aromatic), 2977, 2924 (CH aliphatic), 1606 (C=C), 1549 (C=N), 1059 (N-N), 851 (C-S). 1H NMR (400 MHz, CDCl3, 25C, ppm) : 8.53 (s, 1H, ArH), 8.29 (s 1H, ArH), 8.03 (d, 1H8.4, ArH), 7.78 (d, 1H8.4, ArH), 7.71 (s 1H, ArH), 2.62 (s, 3H, OCH3). Anal. Calcd. for C12H8N6S: C, 53.72; H, 3.01; N, 31.32; S, 11.95. Found out: C, 52.82; H, 3.05; N, 32.50; S, 11.86. 7-Methoxytetrazolo[5′,1′:2,3][1,3,4] thiadiazepino 196868-63-0 supplier [7,6-b]quinoline (3h) Produce: 88%; mp a lot more than 300C; IR (KBr) cm-1: 3007 (CH aromatic), 2932, 2835 (CH aliphatic), 1621 (C=C), 1489 (C=N), 1023 (N-N), 849 (C-S). 1H NMR (400 MHz, CDCl3, 25C, ppm) : 8.52 (s, 1H, ArH), 8.29 (s 1H, ArH), 8.04 (d, 1H8.4, ArH), 7.78 (d, 1H8.4, ArH),.