Background Obvious cell odontogenic carcinoma (CCOC) is usually a rare intraosseous carcinoma of the jaw; only 81 cases have been reported in the English literatures. were mixed type). Thus, the possibility of misdiagnosis is usually relatively high, and the lesion could undergo decompression or curettage before pathologic examination. A radiolucent lesion with jaw enlargement and loosening teeth should be considered to possibly be malignant CCOC in order to identify and treat patients appropriately. CCOC is also hard to diagnose histopathologically. The differential diagnosis of jaw tumors with prominent cytoplasmic clearing includes Rabbit polyclonal to ALKBH1 intraosseous salivary gland tumors (epithelial-myoepithelial carcinoma) and metastatic tumors (obvious cell renal cell carcinoma). Other odontogenic tumors may also show clearing of their constituent cells. Such tumors include calcifying epithelial odontogenic tumor and obvious cell ameloblastoma. While the former is recognized by the presence of psammomatous calcifications and amyloid deposits, the latter may be hard to distinguish from CCOC [13]. In fact, some authors thought that obvious cell ameloblastomas and CCOCs might represent STA-9090 cost a clinicopathological continuum of a single neoplastic entity [14]. In addition, obvious cell carcinoma and CCOC STA-9090 cost are hard, and in some cases, impossible to distinguish morphologically and immunohistochemically, despite a different cell of origin. Bilodeau et al. [15] suggested that location is the most important distinguishing criterion for these tumors. In CCOC, surgical resection with a wide margin is the treatment of choice. Thus, proper jaw reconstruction is usually important and should be performed simultaneously with resection. Fibular free flap reconstruction is necessary when the resected jaw defect is usually large in the mandible; it provides several advantages over other donor sites, including adequate bone length, ease of graft dissection and contouring, a two-team approach, long pedicles with proper vessels, and minimal donor site morbidity. In this case, we obtained an adequate bone length (115?mm) and were able to reconstruct the mandible with satisfactory esthetics and no complications. Conclusions Our survey of the English literature demonstrates that CCOC occurs to STA-9090 cost 5th to 7th decades in women in the mandible with painless swelling. In this case, the patient experienced a different symptom such as a painful toothache without swelling. We also found that it has a good prognosis after surgery. Radiographic images of CCOC generally demonstrate radiolucency but occasionally they are mixed. The differential diagnosis is broad, so a careful approach is necessary both clinically and immunohistochemically. In a large CCOC in mandible cases, wide resection and composite fibula free flap reconstruction is the treatment of choice. Consent Written informed consent was obtained from the patient for publication of this manuscript and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal. Acknowledgements This research was supported by the International Research & Development Program of the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning(Grant number: 2014K1A3A9A01033785). Footnotes Competing interests The authors declare that they have no competing interests. Authors contributions All authors read and approved the final manuscript. IJ read and published the manuscript. SM prepared the figures and published the manuscript. EK collected the literature data. HM designed the article. JH arranged this short article. And SK prepared the histopathologic data. Contributor Information Ik Jae Kwon, Email: moc.liamg@38codelims. Soung Min Kim, Phone: STA-9090 cost +82-2-2072-0213, Email: rk.ca.uns@5nims. Hoon Myoung, Email: rk.ca.uns@hgnuoym. Jong STA-9090 cost Ho Lee, Email: rk.ca.uns@hgnojeel. Suk Keun Lee, Email: ten.liamnah@eelnuekkus..