Dopaminergic neurons in the substantia nigra (SN) selectively die in Parkinsons disease (PD), nonetheless it is usually unclear how and just why this occurs. H-89, two structurally unique high-affinity PKA inhibitors, abolished the protecting aftereffect of butaprost, implicating cAMP-dependent PKA activity in the neuroprotection by EP2 activation. Finally, we display that melanized dopaminergic neurons in… Continue reading Dopaminergic neurons in the substantia nigra (SN) selectively die in Parkinsons