In cells containing disrupted spindles, the spindle assembly checkpoint arrests the cell routine in metaphase. adequate for APC/C inhibition and metaphase arrest (D’Angiolella et al., 2001; Tunquist et al., 2002). The system where cyclin E/Cdk2 inhibits the APC/C isn’t clear, 320-67-2 but is probable related to the overall system where G1 Cdks switch off the… Continue reading In cells containing disrupted spindles, the spindle assembly checkpoint arrests the