Supplementary Materialsmolecules-24-01303-s001. 1000-nm. In vivo, LNPs ready from PEG-OligoRNA-hybridized mRNA exhibited high structural balance in natural milieu, without developing detectable aggregates in 405911-17-3 mouse bloodstream after intravenous shot. On the other hand, LNPs from non-PEGylated mRNA produced many micrometer-sized aggregates in bloodstream, leading to speedy clearance from blood circulation and deposition of the aggregates in… Continue reading Supplementary Materialsmolecules-24-01303-s001. 1000-nm. In vivo, LNPs ready from PEG-OligoRNA-hybridized mRNA exhibited