Centered about classical colchicine site ligands and a computational magic size of the colchicine binding site about beta tubulin, two classes of chalcone derivatives were designed, synthesized and evaluated for inhibition of tubulin assembly and toxicity in human being cancer cell lines. assembly mainly because potently mainly because colchicine. The most potent chalcones inhibited the… Continue reading Centered about classical colchicine site ligands and a computational magic size