The mechanisms underlying granulocyte-colony stimulating factor (G-CSF)-induced mobilization of granulocytic lineage cells from your bone marrow to the peripheral blood remain elusive. Gfi-1 binds to DNA sequences upstream of the gene and represses CXCR4 manifestation in myeloid lineage cells. As a consequence myeloid cell reactions to the CXCR4 unique ligand MEK162 SDF-1 are reduced. Thus… Continue reading The mechanisms underlying granulocyte-colony stimulating factor (G-CSF)-induced mobilization of granulocytic lineage