The etiology and pathogenesis of primary achalasia are unidentified. 21.4% frequency of glutamic acid decarboxylase-65 (GAD65) antibody in individuals with achalasia (versus 2.5 % in control subjects), in the absence of diabetes or companion antibodies predictive EKB-569 of type 1 diabetes. This profile of autoantibodies suggests an autoimmune basis for any subset of main achalasia.… Continue reading The etiology and pathogenesis of primary achalasia are unidentified. 21.4% frequency