LAPTM5 is a lysosomal transmembrane protein expressed in immune cells. UIM is usually retained in the Golgi as is usually LAPTM5 expressed in cells in which Nedd4 or GGA3 is usually knocked-down with RNAi. However ubiquitination-impaired LAPTM5 can still traffic to the lysosome suggesting that Nedd4 binding to LAPTM5 not LAPTM5 ubiquitination is required for… Continue reading LAPTM5 is a lysosomal transmembrane protein expressed in immune cells. UIM