The highly charged histone N-terminal domains are engaged in inter- and intra-nucleosomal interactions and include a host of sites employed for posttranslational modification. repressed non-silenced locus. Nuclease digestive function studies suggest that H2B Δ30-37 chromatin provides increased nucleosome ease of access and/or nucleosome flexibility. Furthermore H2B Δ30-37 mutants acquire even more DNA harm in comparison… Continue reading The highly charged histone N-terminal domains are engaged in inter- and