Background The endothelial nitric oxide synthase cofactor tetrahydrobiopterin (BH4) is vital for maintenance of enzymatic function. haplotype (XX) and 40 without the haplotype (OO) underwent vaccination. XX individuals were unable to BI-1356 supplier increase plasma BH4 and experienced a greater reduction of flow-mediated dilation than OO individuals. In Study 4, vessel segments from 19 individuals… Continue reading Background The endothelial nitric oxide synthase cofactor tetrahydrobiopterin (BH4) is vital