Supplementary Materialsmmc1. respectively, while PGE2, IL-1, and LTD4 experienced no effect. Conclusions KCNQ1/KCNE3 channels make only a small contribution to basolateral conductance in normal colonic crypts, with increased channel activity in UC appearing insufficient to prevent colonic cell depolarization in this disease. This supports the proposal that defective Na+ absorption rather than enhanced Cl? secretion,… Continue reading Supplementary Materialsmmc1. respectively, while PGE2, IL-1, and LTD4 experienced no effect.