Background Mechanical ventilation (MV) is a life-saving intervention in patients with acute respiratory failure. animal model of MV using a highly specific CH5424802 UPP inhibitor epoxomicin to prevent MV-induced activation of the proteasome in the diaphragm (n = 8/group). Results Our results reveal that inhibition of the UPP did not prevent ventilator-induced diaphragm muscle fiber… Continue reading Background Mechanical ventilation (MV) is a life-saving intervention in patients with