An endogenous metabolite of 17-estradiol, 2-methoxyestradiol (2-ME), has affinity for estrogen receptors. cell death induced by the upregulation of phosphorylated extracellular-signal-regulated kinase 1/2 signaling pathway. The results of the present study exhibited that 2-ME, which is usually used as a therapeutic agent for treating solid tumors, exhibits apoptotic and anti-proliferative effects depending on the dose.… Continue reading An endogenous metabolite of 17-estradiol, 2-methoxyestradiol (2-ME), has affinity for estrogen