Internal tandem duplication (ITD) mutations within the FMS-Like Tyrosine Kinase gene (FLT3) render the receptor constitutively energetic, driving a car proliferation and survival in leukemic blasts. 2002; Levis Meters, 2003; Stirewalt DL, 2003). Found out in around 23% of AML instances, an ITD mutation abrogates the unfavorable regulatory function of the juxtamembrane domain name, making… Continue reading Internal tandem duplication (ITD) mutations within the FMS-Like Tyrosine Kinase gene
Tag: NVP-TAE 226
This work defines the in vivo role of phosphorylation of Ser1700
This work defines the in vivo role of phosphorylation of Ser1700 and Thr1704 in CaV1. by -adrenergic/cAMP signaling via phosphorylation by PKA in the fight-or-flight response, but the sites of regulation are unknown. We describe the functional role of phosphorylation of Ser1700 and Thr1704sites of phosphorylation by PKA and casein kinase II at the interface… Continue reading This work defines the in vivo role of phosphorylation of Ser1700