6 g53 wild-type cancers cell lines from infrequently g53-mutated organizations (neuroblastoma, rhabdomyosarcoma, and most cancers) were continuously exposed to increasing concentrations of the murine increase minute 2 inhibitor nutlin-3, resulting in the introduction of nutlin-3-resistant, g53-mutated sublines displaying a multi-drug level of resistance phenotype. U2Operating-system osteosarcoma cells and HCT116 digestive tract cancer tumor cells lead… Continue reading 6 g53 wild-type cancers cell lines from infrequently g53-mutated organizations (neuroblastoma,
Tag: OSI-027
Hormones and growth factors induce the activation of a number of
Hormones and growth factors induce the activation of a number of protein kinases OSI-027 that belong to the AGC subfamily including isoforms of PKA protein kinase B (also known as Akt) PKC S6K p70 (ribosomal S6 kinase) RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated protein kinase) which then mediate many of the… Continue reading Hormones and growth factors induce the activation of a number of