Placing the adequate dose for voriconazole is usually challenging due to its variable pharmacokinetics. we developed. Assuming 50% protein binding on average and an upper limit of 5.5 mg/liter for total voriconazole concentrations, the upper limit for unbound voriconazole concentrations is 2.75 mg/liter. Alterations in voriconazole unbound concentrations caused by hypoalbuminemia and/or elevated bilirubin plasma… Continue reading Placing the adequate dose for voriconazole is usually challenging due to