The objective of this study was to investigate the effect of combined Ca2+ cross-linking and freeze-thawing cycle method on metronidazole (model drug) drug release and prepare a wound film dressing with improved swelling property. repeated freeze and thawing (13) or chemically ionotropic gelation using polyelectrolytes (14). Combined Ca2+ cross-linking and freeze-thawing cycles had been reported… Continue reading The objective of this study was to investigate the effect of