γ-Secretase undergoes endoproteolysis of its catalytic subunit presenilin (PS) to create PS N-terminal and C-terminal fragments (PS1-NTF/CTF) which generate the active site. TM substrates that have undergone ectodomain shedding. Some important γ-secretase RITA (NSC 652287) substrates include amyloid precursor protein (APP) Notch and E-cadherin. γ-Secretase plays a pivotal role in Alzheimer’s disease (AD) and cancer… Continue reading γ-Secretase undergoes endoproteolysis of its catalytic subunit presenilin (PS) to create