Nurr1 (NR4A2) is a transcription factor that belongs to the orphan NR4A group of the Sulfo-NHS-Biotin nuclear receptor superfamily. lacking its first LXXLL motif (PIASγmut1). This PIASγmut1 is also unable to interact with Nurr1 and to repress Nurr1 Mouse monoclonal to GSK3 alpha transcriptional activity. Interestingly the mutant PIASγC342A that lacks SUMO ligase activity is… Continue reading Nurr1 (NR4A2) is a transcription factor that belongs to the orphan