Supplementary MaterialsSupplementary Materials and Figures 41598_2017_5002_MOESM1_ESM. from the non metastatic line (SW480Exos). SWATH-based quantitative proteomic analysis highlighted that SW620Exos are significantly enriched in cytoskeletal-associated proteins including proteins activating the RhoA/ROCK pathway, known to induce amoeboid properties and destabilization of endothelial junctions. In particular, thrombin was identified as a key mediator of the effects induced by… Continue reading Supplementary MaterialsSupplementary Materials and Figures 41598_2017_5002_MOESM1_ESM. from the non metastatic line