An immunosuppressive motif was recently found within the HIV-1 gp41 fusion protein (termed immunosuppressive loop-associated determinant core motif (ISLAD CM)). the d- and l-forms preferentially bound spleen-derived T-cells over B-cells by 13-fold. Furthermore both forms of ISLAD CM co-localized Y-33075 with the TCR on triggered T-cells and interacted with the transmembrane website of the TCR.… Continue reading An immunosuppressive motif was recently found within the HIV-1 gp41 fusion